New research findings are reported in Net Results EXPRESS—the UHN Research e-newsletter that is distributed monthly to all UHN employees and is made publicly available through the UHN Twitter and Facebook pages.

Current and past issues of Net Results EXPRESS are linked below (in HTML format):

April 2012

• Cancer: A New Understanding of Immune System Responses
• Breast Cancer: Gene Signatures for Better Treatments
• Spinal Cord Injury: Reducing Inflammation with a Smart Material
• Diabetes: New Insight into Insulin Release
• Prostate Cancer: Predicting Recurrence using Oxygen Levels
• Stroke Rehabilitation: Determining Fall Prevention Responses in Stroke Patients

March 2012

• Stroke: Development of World’s Most Advanced Neuroprotective Drug
• Proteomics: A Novel Method to Identify Stem Cell Types
• Medical Imaging: Novel Tools for Visualizing Tumours Using Nanotechnology
• Metabolism: Appetite Control in the Brain
• Rehabilitation: Psychotherapy Promotes Prolonged Benefits in Patients with Brain Injury
• UHN Licensed Image Guided Irradiator System Reaches 10th Installation Milestone

February 2012

• Structural Biology: Looking Into the Mechanics of Calcium Release
• Development: Imprinting in the Mouse Genome
• Breast Cancer: Risks and Benefits of Prevention
• Neurology: Controlling the Growth of Neurons
• Stroke: Exercise Program for Rehabilitation
• Cancer: Preventing Tumours in Retinoblastoma

January 2012

• Ovarian Cancer: Drug Delays Disease Progression
• Immunity: Regulating the Response to Infection
• Hormone Therapy: Ontario Failing to Treat Osteoporosis-Related Side Effects
• Metabolism: How the Gut Controls Glucose Production
• Immunology: A New Model for Injury Repair in the Eye
• Social Media: The Role of Twitter in Assessing Scientific Impact

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December 2011: Year in Review

November 2011

• UHN and University of Toronto Launch Techna Institute
• iDAPT: World Class Innovation at Toronto Rehab
• Prostate Cancer: Combination Treatment Greatly Improves Survival
• Cardiology: Sodium Intake Increases Risk of Sleep Apnea
• UHN Educational Tool Licensed to Edwards Lifesciences
• Inflammatory Arthritis: Identifying Risk of Disease Progression

October 2011

• PMH Awarded Third National Cancer Institute Contract
• Immune Disorders: New Insights into Cell Regulation
• Immunity: Cell Adhesion in Leukocytes
• Neurology: Uncovering Factors Associated with the Development of Neurons
• Clinical Trials: The Impact of Announcements on Company Stock Prices
• Alzheimer’s Disease: Quality of Life Assessed by Family Caregivers

September 2011

• UHN Medical Imaging Tool Licensed to Vexim SA
• Cancer: Creating a Blueprint of Protein Modifications
• Cardiology: Distinguishing the Mechanisms of Heart Contraction
• Psoriatic Arthritis: The Disease within a Disease
• Pulmonary Disease: Increasing Physical Activity
• Nanomedicine: Delivery of Anticancer Drugs
• Cardiology: Reducing Inflammation in Damaged Cardiac Muscle
• Stroke Prevention: Assessing the Effects of Surgical Revascularization

August 2011

• Strategic Planning Needs Your Help
• Autoimmune Diseases: Explaining the Role of PTPN22 in Immunity
• Leukemia: Stem Cell Properties Correlate with Disease Outcome
• Immunity: Identifying the Mechanisms Involved in Inflammation of the Colon
• Spondyloarthritis: Impact on Social Life
• Radioisotope Therapy: The Future of Antibody Linked Radiotherapy
• Osteoporosis: Better Prevention from Future Injury

July 2011

• UHN's New Office of Research Trainees
• Stem Cells: Isolation of the Purest Blood Stem Cells
• Clinical Trials: Assessing the Effects of Unpublished Data
• Gastroenterology: New Insights into Blood Glucose Regulation
• Blood: New Directions for Disease Treatment
• Stroke: Understanding the Short-Term Outcomes for Artery Blockage

June 2011

• UHN and Toronto Rehabilitation Institute Announce Their Integration
• Neurology: Stimulation of the Motor Cortex Improves Hand Tremors
• Leukemia: New Cancer Stem Cell Factor Identified
• Cardiology: New Role for Protein in Heart Function
• Myeloma: Antitumour Activity with New Therapeutic Drug
• Stem Cells: Characterizing Neural Stem Cell Development

May 2011

• Health Services Research at UHN: Strategic Planning Workshop
• Prostate Cancer: New Findings on the Effects of Supplements
• Cancer: A New Mechanism for Resistance to Therapy
• Leukemia: Helping the Immune System Fight Cancer
• Parkinson’s Disease: Enhancing the Therapeutic Benefits of L-DOPA
• Neuroscience: Understanding the Effect of Seizures in Stroke Patients
• Acute Lung Injury: New Insight into Factors Involved in Cell and Tissue Damage

April 2011

• Lung Transplantation: High-Risk Donor Lungs Can Now Be Safely Used for Transplant
• Respiratory Disease: Long-Term Study on the Effects of Acute Illness
• Lung Cancer: Changes in Non-Cancer Cells May Predict Patient Outcome
• Diabetes: New Guidelines for Treating Diabetic Neuropathy
• Neurology: Surgical Procedure Reverses Loss of Brain Matter
• Autoimmune Disease: New Suppressor Gene Discovered in Lupus-Prone Mice

March 2011

• Cancer: Novel Organic Nanoparticles for Cancer Targeting and Treatment
• Cardiology: Novel Peptide Helps to Prevent Damage Following Cardiovascular Injury
• Pancreatic Cancer: Hypoxia Predicts Growth and Metastasis
• Stroke: Why Sleeping Better is Good for Stroke Patients
• Intracerebral Hemorrhage: Identifying a Culprit in Brain Injury
• Arthritis: Examining Workplace Activity Limitations

February 2011

• Leukemia: Uncovering Genetic Diversity in Propagating Cells
• HIV Infection:  Promoting the Immune Response to Chronic Viral Infections
• Regenerative Medicine: Development of Heart Cells from Stem Cells
• Depression: Deep Brain Stimulation Shows Benefit in 3 and 6 Year Follow-Up Study
• Parkinson Disease: New Insights into the Role of the Cerebellum in Disease Development
• Heart Disease: A Novel Mechanism of Electrical Remodeling in Cardiac Hypertrophy and Heart Failure

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December 2010: Year in Review

October 2010

• Cancer: Identifying the Cells that Cause Cancer
• Lung Cancer: Gene Signature Helps Predict Benefits of Chemotherapy
• Neuroscience: The Cellular Basis of Neural Impulse Transmission
• Heart Disease: Preventing Injury Following Transplantation
• Diabetes: Detecting Sugar Sensing Pathways in the Brain
• Virology: Developing New Methods to Fight off SARS
• Parkinson's Disease: Learning the Benefits of Combined Therapy

September 2010

• Primary Biliary Cirrhosis: Confirming Gene Involvement
• Leukemia: Timing DNA Repair and Cell Death to Prevent Cancer
• Alzheimer's Disease: Investigating New Stimulating Treatment Techniques
• Neurology: Understanding How Perception of Pain Affects Recovery

July 2010

• Influenza A: Identifying New Cell Populations to Battle Disease
• Immunity and Disease: Applying Cell Therapy to Combat Infectious Disease
• Hodgkin Lymphoma: Investigating Heart Disease Risk and Cancer Treatment
• Lupus: Monitoring Heart Disease Risk in Patients
• Parkinson’s Disease: Understanding the Anatomy of Movement

June 2010

• ELLICSR Opens its Doors
• Immune System: Revising the ‘Road Map’ of Blood Development
• Malignant Mesothelioma: Identifying New Investigative Tools
• Cancer: Depression in Patients with Advanced Disease
• Neurology: Targeting Brain Communication Circuits to Understand Disease

May 2010

• UHN Captures $30M in New Ministry Funding
• Breast Cancer: Hormone-Driven Cell Growth
• Irritable Bowel Syndrome: Brain Landscape Changes and Disrupted Communication
• Neurology: Determining When to Re-Start Anticoagulation
• Diabetes: Locating the Brain’s ‘Sweet Spot’

April 2010

• Structural biology: Understanding How Cells Anchor
• Malaria: How Maternal Infection Contributes to Low Birth Weight
• Lymphoma: Opening the Door to New Research and Treatments
• Lung Cancer: Economic Analysis of Targeted Therapy
• Parkinson's Disease: Learning the Long-Term Effects of Deep Brain Stimulation

March 2010

• Lupus: Investigating Antimalarial Treatments
• Head and Neck Cancer: Using Global Screens for New Target Identification
• Lung Injury: Getting to the Bottom of Injury Promotion and Prevention
• Neurology: Establishing a Circulation and Brain Landscape Relationship

February 2010

• Leukemia: Elucidating Genetic Areas of Control
• Heart Failure: Tracking Patients after Discharge
• Cancer: Understanding Timing and Tumor Development
• Liver Transplant: Determining When and Why to Apply the Surgical Brakes
• Regenerative Medicine: Repairing the Injured Spinal Cord
• Rett Syndrome: Surveying Brain Patterns to Increase Disease Knowledge

January 2010

• Cancer: Changing Current Understanding of Gene Function
• Leukemia: New Population of Cells Discovered
• Cancer Biology: Sensitizing ‘Tenacious’ Tumor Cells
• Neurology: Detailing the Memory Process
• Cardiology: Re-Examining Protective Properties of Beta-Blockers

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December 2009: Year in Review

November 2009

• Lung Transplantation: Gene Therapy Repairs Injured Lungs
• Head & Neck Cancer: Clarifying Trial Terminology
• Parkinson’s Disease: ‘Stimulating’ Ways to Prevent Falls
• Diabetes: Focusing on Early Diabetes Complications
• Brain Injury: Understanding Factors Contributing to Damage
• Breast Cancer: Understanding the Relationship between Treatment and Menopause

October 2009

• Atherosclerosis: Outlining Disease Beginnings
• Cardiology: Understanding the Benefits of Salt
• Stroke: Suppressing Brain Cell Death
• Neurology: Mapping Nerve Changes
• Oral Cancer: Identifying New Biomarkers of Disease
• Nasopharyngeal Cancer: Elucidating Disease Proteins

September 2009

• Lung Cancer: Enhancing the Decision-Making Process
• Diabetes: New Protein Discovery
• Neurology: Changing Current Beliefs
• Cancer: Identifying New Potential Drug Use
• Malaria: Defining Future Treatment Options
• Neurology: Preventing Ocular Cell Death

July 2009

• New CFI Funding Announced
• AL-amyloidosis: Discovering Treatment Strategies
• Cardiovascular Disease: Treatment Implications
• Regenerative Medicine: Defining Growth Requirements
• Parkinson’s Disease: Mapping the Effects of Stimulation

June 2009

• Primary Biliary Cirrhosis: Grabbing Hold of Genetics
• Ovarian Cancer: Patupilone Phase I Safety Findings
• Arthritis: Taking a Closer Look at Gender
• Lung Transplantation: Dealing with Rejection
• Esophageal Cancer: Identifying Markers of Disease

May 2009

• Cancer: Boosting the Body’s Immune System
• Breast Cancer: Assessing Risk Early-On
• Malaria: Pregnancy and Treatment
• Noonan Syndrome: Discovering the Mechanics of Disease
• ADHD: Genetics of Disease
• Kidney Disease: Identifying Growth Pathways

April 2009

• Malaria: Biomarker Discovery
• Liver Cancer: Novel Treatment Strategy
• Parkinson’s Disease: Deciphering Cell Communication
• Neurology: Imaging the Brain
• Breast Cancer: Revisiting Treatment Strategies

March 2009

• Cancer: Using Algorithms to Detect Gene Patterns
• Lung Cancer: Three-Sided Approach to Treatment
• Neurology: Exploring the Use of New Research Tool
• Major Depressive Disorder: Profiling Treatment
• HIV: Evaluating New Therapy Options

February 2009

• Cancer: New Technology to Study Structure
• Regenerative Medicine: Novel Findings for Lung Repair
• Cardiology: Avoiding Acute Kidney Injury
• Cancer: The Genetics Behind Chronic Myeloid Leukemia
• Ankylosing Spondilitis: Discovering Biomarkers of Disease

January 2009

• Cancer: Illustrating Form and Function
• Cancer: Outpatient Palliative Care Interventions
• Parkinson’s Disease: Investigating Brain Cell Connections
• Lupus: Monitoring the Advantages of Methotrexate
• Thyroid Cancer: Revealing Where Growth Starts
• Virology: The Mechanisms of Infection

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December 2008: Year in Review - UHN Research in 2008

November 2008

• Directing Heart Cell Development
• 'Checking' Immune Cell Balance
• Remodeling the Heart After Injury
• Surprising New Model for Cancer Cell Aging
• Psoriatic Arthritis Researchers Tackle Fatigue
• Weight Management Prediction in Anorexia

October 2008

• Signal Control in Immunity
• Thyroid Cancer Cells 'Staying Put'
• 'Current' Neural Regenerative Medicine
• Injury Mechanics in Neurology

September 2008

• Landmark $120M Funding to UHN
• Cancer Protein and Male Infertility
• Forecasting Hepatitis with Disease Marker
• ‘Report’ing on the Immune System
• Indicators of Lung Cancer Therapy Response
• Eating Behaviors in Diabetic Teen Girls

July 2008

• Enzyme Deficiency in Malaria
• Genetic Changes Involved in Colorectal Cancer
• A New Therapeutic Approach for Hepatitis B
• Family Involvement in Psoriatic Arthritis
• How Hospital and Surgeon Volume Affects Prostate Cancer
• Movement Control Tactics in Parkinson’s Disease

June 2008

• Tuning the 'Engine' of Immune Response
• The Role of Fat in Diabetes and Cardiology
• Innovative Cancer Treatment Moves to Phase II
• Defining Mechanisms of Brain Degeneration

May 2008

• Regenerative Medicine and Cardiac Cells
• Three-Way Communication in Diabetes
• Controlling the Host Response in Malaria
• Arthritis Medication Raises Caution
• New Potential for Parkinson's Disease
• Understanding Growth in Pituitary Cancer
• Lung Cancer and Immune Cells
• New Predictors in Prostate Cancer

April 2008

• Hypertrophy and Cardiac Cells
• Nomograms for Phase II Clinical Trials
• Stroke and the Penumbra
• Decision Aids for Cancer Patients

March 2008

• Smooth Muscle Cells in Cardiology
• Revisiting Survival in Prostate Cancer
• Alzheimer's Disease and DBS
• Gene Targeting in Rett Syndrome
• Retinoblastoma and Genomic Instability
• Disease Management in Lupus
• Couples Intervention for Cancer

January 2008

• New Tool for Stem Cells
• 3D Liver Cancer
• Lupus Development
• Profiling Cerebral Malaria
• IBS and Pain
• Treating Type II Diabetes

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Previous issues of Net Results EXPRESS can be viewed in the archive.